Ketogenic Diet and Glucose Control

Ketogenic diet: Predictors of seizure control

BACKGROUND The ketogenic diet is an effective non-pharmacologic treatment for medically resistant epilepsy. The aim of this study was to identify any predictors that may influence the response of ketogenic diet. METHODS A retrospective chart review for all patients with medically resistant epilepsy was performed at a tertiary care epilepsy center from 1996 to 2012. Patient- and diet-related v...

Ketosis, ketogenic diet and food intake control: a complex relationship

Though the hunger-reduction phenomenon reported during ketogenic diets is well-known, the underlying molecular and cellular mechanisms remain uncertain. Ketosis has been demonstrated to exert an anorexigenic effect via cholecystokinin (CCK) release while reducing orexigenic signals e.g., via ghrelin. However, ketone bodies (KB) seem to be able to increase food intake through AMP-activated prote...

Ketogenic diet. Update and application.

The ketogenic diet is a high-fat, low-carbohydrate, and adequate-protein diet for the treatment of intractable seizures in children, initially introduced in 1921 to mimic the biochemical changes associated with fasting. The diet is individually calculated and rigidly controlled, requiring a comprehensive medical team approach. Although there are adverse, as well as, beneficial effects, several ...

The Ketogenic Diet

Seizure control by ketogenic diet-associated medium chain fatty acids

The medium chain triglyceride (MCT) ketogenic diet is used extensively for treating refractory childhood epilepsy. This diet increases the plasma levels of medium straight chain fatty acids. A role for these and related fatty acids in seizure control has not been established. We compared the potency of an established epilepsy treatment, Valproate (VPA), with a range of MCT diet-associated fatty...